Analysis of functional score in adult primary brain tumor patients: A single institution study

Authors

  • Wismaji Sadewo Department of Neurosurgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
  • Starleen Elexia Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
  • Aria Kekalih Department of Community Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
  • Muhammad Saekhu Department of Neurosurgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
  • Muhammad Aulia Rahman Department of Neurosurgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
  • Fabianto Santoso Department of Neurosurgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
  • Setyo Widi Nugroho Department of Neurosurgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
  • Mikha University of Indonesia
  • Nazamta Yusfiatuzzahra Department of Physical Medicine and Rehabilitation, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
  • Nashruta Nisatul A'la Department of Neurosurgery, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia

DOI:

https://doi.org/10.54029/2026ikx

Keywords:

Brain Neoplasm, Functional outcomes, Karnofsky Performance Status, tumor size, tumor type, tumor location

Abstract

Objectives: This study investigates the relationships between preoperative functional scores, tumor type, size, and location, as well as postoperative functional outcomes in brain tumor patients.

Methods: A retrospective cohort design analyzed medical records of adult brain tumor patients at Cipto Mangunkusumo Hospital (RSCM) from 2021 to 2022. Inclusion criteria were adults aged 17 years and older diagnosed with primary brain tumors confirmed by CT or MRI imaging. Consecutive sampling was utilized for selection. Data analysis included univariate tests for descriptive statistics and bivariate hypothesis tests (Mann-Whitney, T-test, Kruskal-Wallis, ANOVA) to assess variable relationships, with significance set at p < 0.05.

Results: From 456 samples, 255 met the criteria for analysis. The median age was 44 years, with a predominance of females (66.7%). Meningiomas were the most common tumor type (43.5%). The median tumor size was 27.972 cc, with 91.4% located supratentorially. Preoperative Karnofsky Performance Status (KPS) scores had a median of 80%. Significant relationships were found between tumor type and preoperative KPS scores (p < 0.001) and a weak negative correlation between tumor size and KPS scores (correlation coefficient = -0.194). Supratentorial tumors had higher preoperative KPS scores compared to infratentorial tumors (median 80% vs. 75%, p < 0.05).

Conclusion: Tumor characteristics significantly influence functional outcomes in brain tumor patients, highlighting the importance of these factors in management strategies.

Published

2026-03-23

Issue

Vol. 31 No. 1 (2026)

Section

Original Article